| Game | Region | Rating | Download |
|---|
| SD Valis |  |  | |
| SEGA Master System Brawl (Aftermarket) (Homebrew) |  | | |
| ST II' Turbo (Proto) (Pirate) |  | | |
| Sacred Line Genesis (1.1.9) (Aftermarket) (Unl) | | | |
| Sacred Line Genesis (Aftermarket) (Unl) | | | |
| Sacred Line Zero (Proto) (Aftermarket) (Unl) | | | |
| Sagaia | | | |
| Saint Sword | | | |
| Saint Sword | | | |
| Same! Same! Same! (Beta) (1990-07-30) | | | |
| Same! Same! Same! | | | |
| Sampras Tennis 96 (J-Cart) |  | | |
| Samurai Shodown | | | |
| Samurai Shodown | | | |
| Samurai Spirits | | | |
| Samurai Spirits II (Unl) (Alt) |  | | |
| Samurai Spirits II (Unl) | | | |
| San Guo Yan Yi - Huo Shao Chi Bi (Unl) | | | |
| San Guo Zhi Lie Zhuan - Luan Shi Qun Ying |  | | |
| Sangokushi II | | | |
| Sangokushi III | | | |
| Sangokushi Retsuden - Ransei no Eiyuutachi | | | |
| Sangokushi V (Unl) | | | |
| Sansan | | | |
| Saturday Night Slammasters | | | |
| Saturday Night Slammasters | | | |
| Schtroumpfs Autour du Monde, Les | | | |
| Scooby-Doo Mystery | | | |
| Scrabble (Proto) | | | |
| Second Samurai | | | |
| Second Samurai (Aftermarket) (Unl) | | | |
| Sega Art Tool (Program) | | | |
| Sega Channel (v2.11) (Earlier) (Program) | | | |
| Sega Channel (v2.11) (Program) | | | |
| Sega Channel (General Instrument) (Program) | | | |
| Sega Channel (Scientific Atlanta) (Program) | | | |
| Sega Channel Demo (Program) | | | |
| Sega Sound Tool (v2.2) (Program) | | | |
| Sega Sports 1 | | | |
| Sega Top Five |  | | |
| Senjou no Ookami II ~ Mercs | | | |
| Sensible Soccer (Beta) | | | |
| Sensible Soccer | | | |
| Sesame Street Counting Cafe | | | |
| Shadow Blasters | | | |
| Shadow Dancer - The Secret of Shinobi (PC Rerelease) | | | |
| Shadow Dancer - The Secret of Shinobi (Beta) (1990-10-02) | | | |
| Shadow Dancer - The Secret of Shinobi | | | |
| Shadow of the Beast | | | |
| Shadow of the Beast - Mashou no Okite | | | |
| Shadow of the Beast II | | | |
| Shadowrun | | | |
| Shadowrun (Beta) (1993-12-28) | | | |
| Shadowrun (Beta) (1993-12-31) | | | |
| Shadowrun (Beta) (1994-01-25) (Alt) | | | |
| Shadowrun (Beta) (1994-01-25) | | | |
| Shadowrun | | | |
| Shane Warne Cricket |  | | |
| Shanghai II - Dragon's Eye (Beta) | | | |
| Shanghai II - Dragon's Eye | | | |
| Shaq-Fu | | | |
| Shi Jie Zhi Bang Zheng Ba Zhan - World Pro Baseball 94 (Unl) | | | |
| Shi San Zhang Ma Jiang 98 - Mei Shao Nv (Unl) | | | |
| Shi no Meikyuu - Labyrinth of Death (Game no Kanzume Otokuyou) | | | |
| Shi no Meikyuu - Labyrinth of Death (SegaNet) | | | |
| Shijou Saidai no Soukoban | | | |
| Shikinjou | | | |
| Shin Changsegi - Ragnacenty |  | | |
| Shin Souseiki Ragnacenty (Beta) | | | |
| Shin Souseiki Ragnacenty | | | |
| Shining Force | | | |
| Shining Force (Beta) | | | |
| Shining Force (Genesis Mini) | | | |
| Shining Force | | | |
| Shining Force - Kamigami no Isan (Mega Drive Mini) | | | |
| Shining Force - Kamigami no Isan | | | |
| Shining Force II | | | |
| Shining Force II (Beta) (1994-04-04) | | | |
| Shining Force II (Beta) (1994-06-07) | | | |
| Shining Force II | | | |
| Shining Force II (Switch Online) | | | |
| Shining Force II - Inishie no Fuuin (Switch Online) | | | |
| Shining Force II - Inishie no Fuuin | | | |
| Shining and the Darkness | | | |
| Shining in the Darkness | | | |
| Shining in the Darkness | | | |
| Shinobi III - Return of the Ninja Master | | | |
| Shinobi III - Return of the Ninja Master (Beta) (1993-06-29) | | | |
| Shinobi III - Return of the Ninja Master (Genesis Mini) | | | |
| Shinobi III - Return of the Ninja Master | | | |
| Ship (Proto) (GEMS 2.5) |  | | |
| Ship (Proto) (Visitor) | | | |
| Shiten Myouou | | | |
| Shougi no Hoshi | | | |
| Shove It! ...The Warehouse Game | | | |
| Show do Milhao | | | |
| Show do Milhao Volume 2 | | | |
| Shui Hu - Feng Yun Zhuan (Unl) | | | |
| Shui Hu Zhuan (Unl) | | | |
| Shura no Mon | | | |
| Side Pocket | | | |
| Side Pocket | | | |
| Side Pocket | | | |
| Simpsons, The - Bart vs. the Space Mutants (Rev A) | | | |
| Simpsons, The - Bart vs. the Space Mutants | | | |
| Simpsons, The - Bart's Nightmare | | | |
| Skeleton Krew | | | |
| Skeleton Krew | | | |
| Skitchin' | | | |
| Slam - Shaq vs. the Legends (Proto) | | | |
| Slap Fight MD (Beta) | | | |
| Slap Fight MD | | | |
| Slaughter Sport | | | |
| Slime World | | | |
| Smart Mouse (Aftermarket) (Unl) | | | |
| Smurfs, The | | | |
| Smurfs, The | | | |
| Snake Rattle n Roll | | | |
| Snow Bros. - Nick & Tom | | | |
| Socket | | | |
| Sol-Deace (1992-02-03) (Sega Channel) | | | |
| Sol-Deace | | | |
| Soldiers of Fortune | | | |
| Soleil | | | |
| Soleil |  | | |
| Soleil |  | | |
| Soleil |  | | |
| Sonic & Knuckles (Beta) (1994-05-25) | | | |
| Sonic & Knuckles (Beta) (1994-06-06) | | | |
| Sonic & Knuckles (Beta) (1994-06-08) | | | |
| Sonic & Knuckles (Beta) (1994-06-10) | | | |
| Sonic & Knuckles (Beta) (1994-06-12) | | | |
| Sonic & Knuckles (Beta) (1994-06-18) | | | |
| Sonic & Knuckles (Beta) (1994-06-19) | | | |
| Sonic & Knuckles (Sonic Classic Collection) | | | |
| Sonic & Knuckles | | | |
| Sonic & Knuckles + Sonic The Hedgehog 2 (Beta) (1994-05-24) | | | |
| Sonic 3 | | | |
| Sonic 3D Blast (Beta) (1996-07-03) | | | |
| Sonic 3D Blast (Beta) (1996-08-14) | | | |
| Sonic 3D Blast (Beta) (1996-08-19) | | | |
| Sonic 3D Blast (Beta) (1996-08-25) | | | |
| Sonic 3D Blast (Beta) (1996-08-30) | | | |
| Sonic 3D Blast (Beta) (1996-08-31) | | | |
| Sonic 3D Blast (Beta) (1996-09-04) | | | |
| Sonic 3D Blast - Director's Cut (Unl) | | | |
| Sonic 3D Blast ~ Sonic 3D Flickies' Island | | | |
| Sonic Compilation | | | |
| Sonic Compilation ~ Sonic Classics (Rev A) | | | |
| Sonic Crackers (Proto) (1994-07-xx) | | | |
| Sonic Eraser (SegaNet) | | | |
| Sonic Jam 6 (Unl) | | | |
| Sonic Spinball (Beta) (1993-09-17) | | | |
| Sonic Spinball (Mega Drive Mini) | | | |
| Sonic Spinball | | | |
| Sonic Spinball | | | |
| Sonic Spinball (1993-09-22) (Sega Channel) | | | |
| Sonic Spinball (Beta) (August, 1993) | | | |
| Sonic Spinball (Beta) (October, 1993) | | | |
| Sonic Spinball | | | |
| Sonic The Hedgehog | | | |
| Sonic The Hedgehog (Sonic Classic Collection) | | | |
| Sonic The Hedgehog | | | |
| Sonic The Hedgehog (Beta) | | | |
| Sonic The Hedgehog (Sonic Mega Collection) | | | |
| Sonic The Hedgehog 2 (Beta) (1992-08-21) | | | |
| Sonic The Hedgehog 2 (Beta) (1992-09-14) | | | |
| Sonic The Hedgehog 2 (Beta) (1992-09-18) | | | |
| Sonic The Hedgehog 2 (Beta) (1992-09-21) | | | |
| Sonic The Hedgehog 2 (Beta) (1992-09-22) | | | |
| Sonic The Hedgehog 2 (Beta) (1992-09-24) (Alt) | | | |
| Sonic The Hedgehog 2 (Beta) (1992-09-24) | | | |
| Sonic The Hedgehog 2 (Beta) (July, 1992) | | | |
| Sonic The Hedgehog 2 (Beta) (June, 1992) | | | |
| Sonic The Hedgehog 2 (Beta) (September, 1992) | | | |
| Sonic The Hedgehog 2 (Rev A) (Sonic Classic Collection) | | | |
| Sonic The Hedgehog 2 (Rev A) (Sonic Mega Collection) | | | |
| Sonic The Hedgehog 2 (Rev A) | | | |
| Sonic The Hedgehog 2 (Rev B) | | | |
| Sonic The Hedgehog 2 | | | |
| Sonic The Hedgehog 3 | | | |
| Sonic The Hedgehog 3 (1993-11-20) (Sega Channel) | | | |
| Sonic The Hedgehog 3 (Sonic Classic Collection) | | | |
| Sonic The Hedgehog 3 | | | |
| Sonic The Hedgehog 3 (Beta) (1993-11-03) | | | |
| Sonic The Hedgehog 3 Limited Edition (Proto) (1994-04-08) | | | |
| Sonic The Hedgehog 3 Limited Edition (Proto) (1994-05-17) | | | |
| Sorcer Kingdom (Beta) (1991-11-08) | | | |
| Sorcer Kingdom | | | |
| Sorcerer's Kingdom (Beta) | | | |
| Sorcerer's Kingdom | | | |
| Sorcerian (Rev 1) (Virtual Console) | | | |
| Sorcerian | | | |
| Soul Blade (Unl) | | | |
| Soul Edge VS Samurai Spirits (Unl) | | | |
| Space Funky B.O.B. | | | |
| Space Harrier II (Launch Cart) | | | |
| Space Harrier II | | | |
| Space Hero (Proto) | | | |
| Space Invaders '91 | | | |
| Space Invaders 90 | | | |
| Sparkster | | | |
| Sparkster | | | |
| Sparkster - Rocket Knight Adventures 2 | | | |
| Speedball 2 | | | |
| Speedball 2 | | | |
| Speedball 2 - Brutal Deluxe (Beta) (1991-06-07) | | | |
| Speedball 2 - Brutal Deluxe | | | |
| Spider-Man (Acclaim) (Beta) (1994-12-12) | | | |
| Spider-Man (Acclaim) (Beta) (August, 1994) | | | |
| Spider-Man (Acclaim) | | | |
| Spider-Man (Sega) | | | |
| Spider-Man . Venom - Maximum Carnage | | | |
| Spider-Man X-Men - Arcade's Revenge | | | |
| Spider-Man X-Men - Arcade's Revenge | | | |
| Spiritual Warfare (Unl) | | | |
| Spirou (Beta) | | | |
| Spirou | | | |
| Splatterhouse 2 | | | |
| Splatterhouse 2 (1992-03-02) (Sega Channel) | | | |
| Splatterhouse 2 | | | |
| Splatterhouse 3 | | | |
| Splatterhouse Part 2 | | | |
| Splatterhouse Part 3 | | | |
| Sport Games | | | |
| Sports Talk Baseball | | | |
| Spot Goes to Hollywood | | | |
| Spot Goes to Hollywood | | | |
| Squirrel King (Unl) | | | |
| Star Control (Unl) | | | |
| Star Cruiser | | | |
| Star Odyssey (Beta) (1992-01-16) | | | |
| Star Odyssey (Unl) | | | |
| Star Trek - Deep Space Nine - Crossroads of Time | | | |
| Star Trek - Deep Space Nine - Crossroads of Time | | | |
| Star Trek - The Next Generation (Beta) (1993-12-28) | | | |
| Star Trek - The Next Generation (Beta) (1993-12-29) | | | |
| Star Trek - The Next Generation (Beta) (1994-01-03) | | | |
| Star Trek - The Next Generation (Beta) (1994-01-10) | | | |
| Star Trek - The Next Generation (Beta) (1994-01-18) | | | |
| Star Trek - The Next Generation (Beta) (1994-01-25) | | | |
| Star Trek - The Next Generation - Echoes from the Past (Rev A) | | | |
| Star Trek - The Next Generation - Echoes from the Past | | | |
| Star Wars (Proto) (1993-01-25) | | | |
| Starflight (Rev A) | | | |
| Starflight | | | |
| Stargate (Beta) | | | |
| Stargate (Sample) (NGen) | | | |
| Stargate | | | |
| Steel Empire (1992-03-13) (Sega Channel) | | | |
| Steel Empire | | | |
| Steel Talons | | | |
| Steel Talons (Beta) (Alt) | | | |
| Steel Talons (Beta) | | | |
| Steel Talons | | | |
| Stone Protectors (Proto) | | | |
| Stone Protectors (Steam) | | | |
| Stormlord | | | |
| Stormlord | | | |
| Story of Thor, The (Beta) (1994-10-04) | | | |
| Story of Thor, The (Beta) (1994-10-17) | | | |
| Story of Thor, The (Beta) (April, 1994) | | | |
| Story of Thor, The (Mega Drive Mini) | | | |
| Story of Thor, The | | | |
| Story of Thor, The (Mega Drive Mini) | | | |
| Story of Thor, The | | | |
| Story of Thor, The | | | |
| Story of Thor, The (Mega Drive Mini) | | | |
| Story of Thor, The | | | |
| Story of Thor, The - Hikari o Tsugumono | | | |
| Street Fighter II' - Champion Edition (Beta) (1993-03-25) | | | |
| Street Fighter II' - Champion Edition (Beta) (1993-07-30) | | | |
| Street Fighter II' - Special Champion Edition (Virtual Console) | | | |
| Street Fighter II' - Special Champion Edition | | | |
| Street Fighter II' - Special Champion Edition (Virtual Console) | | | |
| Street Fighter II' - Special Champion Edition | | | |
| Street Fighter II' Plus - Champion Edition (Virtual Console) | | | |
| Street Fighter II' Plus - Champion Edition | | | |
| Street Racer (Beta) (1995-03-21) | | | |
| Street Racer | | | |
| Street Smart (Beta) (1990-06-29) | | | |
| Street Smart | | | |
| Streets of Rage 2 (Mega Drive Mini) | | | |
| Streets of Rage 2 | | | |
| Streets of Rage 3 | | | |
| Streets of Rage 3 (Beta) (1994-04-12) | | | |
| Streets of Rage 3 (Beta) (1994-04-13) | | | |
| Streets of Rage 3 (Beta) (1994-04-15) | | | |
| Streets of Rage 3 (Beta) (1994-04-20) | | | |
| Streets of Rage 3 (Beta) (1994-04-25) | | | |
| Streets of Rage 3 | | | |
| Streets of Rage 3 (Beta) (1994-03-08) | | | |
| Streets of Rage 3 (Beta) (1994-03-17) | | | |
| Streets of Rage 3 (Beta) (1994-03-18) | | | |
| Streets of Rage 3 (Rev A) (Beta) (1994-03-28) | | | |
| Streets of Rage 3 (Rev A) (Beta) (1994-04-01) | | | |
| Streets of Rage 3 (Rev A) (Beta) (1994-04-04) | | | |
| Streets of Rage 3 (Rev A) (Beta) (1994-04-08) | | | |
| Streets of Rage 3 (Rev A) (Beta) (1994-04-11) | | | |
| Streets of Rage 3 (Rev A) (Beta) (1994-04-12) | | | |
| Streets of Rage 3 (Rev A) (Beta) (1994-04-13) | | | |
| Streets of Rage 3 | | | |
| Strider (Virtual Console) | | | |
| Strider | | | |
| Strider Hiryuu (Rev A) (Mega Drive Mini) | | | |
| Strider Hiryuu (Rev A) (Virtual Console) | | | |
| Strider Hiryuu | | | |
| Strider II | | | |
| Striker (Beta) | | | |
| Striker | | | |
| Sub-Terrania (Beta 4) (1994-02-02) | | | |
| Sub-Terrania | | | |
| Sub-Terrania | | | |
| Sub-Terrania (Beta 1) (July, 1993) | | | |
| Sub-Terrania (Beta 2) (October, 1993) | | | |
| Sub-Terrania (Beta 3) (October, 1993) | | | |
| Sub-Terrania | | | |
| Summer Challenge (Unl) | | | |
| Sunset Riders | | | |
| Sunset Riders | | | |
| Super Airwolf | | | |
| Super Baseball 2020 | | | |
| Super Battleship - The Classic Naval Combat Game | | | |
| Super Bubble Bobble (Unl) | | | |
| Super Daisenryaku (Rev A) | | | |
| Super Daisenryaku | | | |
| Super Donkey Kong 99 (Unl) | | | |
| Super Fantasy Zone | | | |
| Super Fantasy Zone | | | |
| Super Fantasy Zone (Genesis Mini) | | | |
| Super H.Q. | | | |
| Super Hang-On (Rev A) | | | |
| Super Hang-On | | | |
| Super Hang-On (Beta) (1989-08-18) (Sega Channel) | | | |
| Super Hang-On (Sega Smash Pack 2) | | | |
| Super Heavy Duty (Aftermarket) (Unl) | | | |
| Super Heavy Duty (Demo) (2020-08-27) (Aftermarket) (Unl) | | | |
| Super High Impact | | | |
| Super Hydlide | | | |
| Super Hydlide | | | |
| Super Hydlide (Beta) (1989-10-16) | | | |
| Super Hydlide | | | |
| Super Kick Off | | | |
| Super King Kong 99 (Unl) | | | |
| Super League | | | |
| Super League | | | |
| Super Mario 2 (Unl) | | | |
| Super Mario Bros. (Unl) | | | |
| Super Mario World (Unl) | | | |
| Super Mario World 64 (Unl) | | | |
| Super Monaco GP | | | |
| Super Monaco GP | | | |
| Super Monaco GP (Rev A) | | | |
| Super Monaco GP | | | |
| Super Off Road (Unl) | | | |
| Super Real Basketball | | | |
| Super Real Basketball | | | |
| Super Shinobi II, The (Beta 1) | | | |
| Super Shinobi II, The (Beta 2) | | | |
| Super Shinobi II, The | | | |
| Super Shinobi, The (Beta) (1989-08-21) (Sega Channel) | | | |
| Super Shinobi, The (Beta) (1989-xx-xx) (Sega Smash Pack) | | | |
| Super Shinobi, The | | | |
| Super Skidmarks (Beta) (1995-09-22) | | | |
| Super Skidmarks (J-Cart) | | | |
| Super Smash T.V. | | | |
| Super Street Fighter II (Virtual Console) | | | |
| Super Street Fighter II | | | |
| Super Street Fighter II (Virtual Console) | | | |
| Super Street Fighter II | | | |
| Super Street Fighter II - The New Challengers (Virtual Console) | | | |
| Super Street Fighter II - The New Challengers | | | |
| Super Tank War (Unl) | | | |
| Super Thunder Blade (Launch Cart) | | | |
| Super Thunder Blade | | | |
| Super Volley Ball | | | |
| Super Volleyball | | | |
| Superman (Beta) | | | |
| Superman | | | |
| Superman - The Man of Steel | | | |
| Surging Aura | | | |
| Swamp Thing (Proto) | | | |
| Sweetsdigger (Aftermarket) (Homebrew) | | | |
| Switchblade (Aftermarket) (Unl) | | | |
| Switchblade (Demo) (Aftermarket) (Unl) | | | |
| Sword of Sodan | | | |
| Sword of Sodan | | | |
| Sword of Vermilion (1993-11-18) (Sega Channel) | | | |
| Sword of Vermilion | | | |
| Syd of Valis | | | |
| Sylvester & Tweety in Cagey Capers (Beta 1) | | | |
| Sylvester & Tweety in Cagey Capers (Beta 2) | | | |
| Sylvester and Tweety in Cagey Capers ~ Sylvester & Tweety in Cagey Capers | | | |
| Syndicate | | | |
| seaQuest DSV | | | |
| seaQuest DSV | | | |
