| Game | Region | Rating | Download |
|---|
| SDI |  |  | |
| Sagaia (Europe, Brazil) |  |  | |
| Sagak-ui Bimil |  | | |
| Samgukji 3 | | | |
Sapo Xule
O Mestre do Kung Fu | | | |
Sapo Xule
S.O.S. Lagoa Poluida (Brazil, Portugal) (Pt) | | | |
| Sapo Xule vs. Os Invasores do Brejo | | | |
| Satellite 7 | | | |
| Les Schtroumpfs Autour du Monde (Beta) (1996-08-12) |  | | |
| Les Schtroumpfs Autour du Monde | | | |
| Scramble Spirits (Europe, Brazil) | | | |
| Scramble Spirits |  | | |
| Secret Command | | | |
| Sega Chess (Europe, Brazil) | | | |
| Sega Graphic Board (v2.0) (Proto) |  | | |
| Sega World Tournament Golf (Europe, Brazil) | | | |
| Seishun Scandal | | | |
| Sensible Soccer | | | |
| Shadow Dancer | | | |
Shadow Dancer
The Secret of Shinobi (Europe, Brazil) | | | |
| Shadow of the Beast (Europe, Brazil) | | | |
| Shadow of the Beast | | | |
| Shanghai (Beta) | | | |
| Shanghai | | | |
| Shangwei Mingling | | | |
| Shinobi (Japan, Brazil) | | | |
| Shinobi (USA, Europe, Brazil) (Rev 1) | | | |
| Shooting Gallery (USA, Europe, Brazil) | | | |
| Simpsons Trivia (v1.00) (Aftermarket) (Homebrew) |  | | |
| Simpsons Trivia (v1.01) (Aftermarket) (Homebrew) | | | |
| Simpsons Trivia (v1.02) (Aftermarket) (Homebrew) | | | |
The Simpsons
Bart vs. The Space Mutants (Europe, Brazil) | | | |
The Simpsons
Bart vs. The World (Europe, Brazil) | | | |
| Sitio do Picapau Amarelo | | | |
| Sky Fighter | | | |
| Sky Jaguar (Clover) | | | |
| Sky Jaguar | | | |
| Slap Shoot (Beta) | | | |
| Slap Shot (Sample) | | | |
| Slap Shot | | | |
| Slap Shot (USA, Europe, Brazil) | | | |
| The Smurfs (Europe, Brazil) | | | |
Solomon no Kagi
Oujo Rihita no Namida (Beta) | | | |
Solomon no Kagi
Oujo Rihita no Namida | | | |
| Sonic Blast | | | |
| Sonic Chaos (Europe, Brazil) (Beta) (1993-06-30) | | | |
| Sonic Chaos (Europe, Brazil) (Beta) (1993-07-13) | | | |
| Sonic Chaos (Europe, Brazil) | | | |
| Sonic Spinball (Europe, Brazil) | | | |
| Sonic The Hedgehog (USA, Europe, Brazil) | | | |
| Sonic The Hedgehog 2 (Europe, Brazil) (Rev 1) | | | |
| Sonic The Hedgehog 2 (Europe, Brazil) | | | |
| Sonic's Edusoft (Proto) |  | | |
| Space Gun | | | |
| Space Harrier | | | |
| Space Harrier | | | |
| Space Harrier 3-D (USA, Europe, Brazil) | | | |
| Space Harrier 3D | | | |
| Special Criminal Investigation (Beta) | | | |
| Special Criminal Investigation | | | |
| Speedball (Rev 1) | | | |
| Speedball | | | |
| Speedball 2 | | | |
| SpellCaster (USA, Europe, Brazil) | | | |
| Spider-Man (USA, Europe, Brazil) | | | |
Spider-Man
Return of the Sinister Six (Europe, Brazil) | | | |
| Sports Pad Football | | | |
| Sports Pad Soccer | | | |
| Spy vs Spy | | | |
| Spy vs Spy | | | |
| Spy vs Spy (USA, Europe, Brazil) | | | |
| Star Wars (Europe, Brazil) | | | |
| Street Fighter II' | | | |
| Street Master | | | |
| Streets of Rage (Europe, Brazil) | | | |
| Streets of Rage II (Europe, Brazil) | | | |
| Strider (USA, Europe, Brazil) (Demo) | | | |
| Strider (USA, Europe, Brazil) | | | |
| Strider II (Europe, Brazil) | | | |
| The Strider | | | |
| Submarine Attack (Europe, Brazil) | | | |
| Submarine Attack | | | |
| Suho Jeonsa | | | |
Sukeban Deka II
Shoujo Tekkamen Densetsu | | | |
| Summer Games (Europe, Brazil) (Beta 1) | | | |
| Summer Games (Europe, Brazil) (Beta 2) | | | |
| Summer Games (Europe, Brazil) | | | |
| Super Arkanoid | | | |
| Super Basketball (Demo) | | | |
| Super Bioman I | | | |
| Super Boy 4 | | | |
| Super Boy I | | | |
| Super Boy II | | | |
| Super Boy III | | | |
| Super Bubble Bobble | | | |
| Super Columns & Tetris | | | |
| Super Futebol II | | | |
| Super Golf (Beta) | | | |
| Super Kick Off (Europe, Brazil) | | | |
| Super Monaco GP (Europe, Brazil) (Beta) | | | |
| Super Monaco GP (Europe, Brazil) | | | |
| Super Monaco GP (Beta) | | | |
| Super Monaco GP | | | |
| Super Off Road (Beta) | | | |
| Super Off Road | | | |
| Super Racing | | | |
| Super Smash T.V. | | | |
| Super Space Invaders | | | |
| Super Tennis | | | |
| Super Tetris | | | |
Super Wonder Boy
Monster World | | | |
Superman
The Man of Steel (Europe, Brazil) | | | |
